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It can express transcription factors Mac1 and Ctr1, which promote copper absorption, and can also avoid toxic effects caused by excessive copper accumulation through its unique plasma membrane structure and the activation of the copper resistance assay gene CRD1 [41,42,43,44,45]

The insulinotropic effect of GIP and GLP-1 is additive in healthy humans but is impaired in people with type 2 diabetes [61]

[DOI] [Google Scholar] 86.Polatolu ., Karata D

GLP-1Rs are not only widely expressed in the central nervous system but also in peripheral nerves such as vagal afferents

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