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Future research should focus on selective inhibition or activation of specific subtypes, combined with techniques such as single-cell sequencing and metabolomics, to clarify their tissue-specific effects

Avoid repeated freeze-thaw cycles of reconstituted solutions, as temperature fluctuations may lead to peptide degradation and reduced biological activity

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Notably, both gender groups demonstrated the potential for AE development beyond the one-year treatment threshold, underscoring the importance of sustained pharmacovigilance throughout the treatment course