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In order to prevent oxidative damage caused by adverse conditions, aquaculture animals must have an effective antioxidant system, such as endogenous free radical scavenging enzymes and exogenous antioxidants ( 2 O 2 ) in the body tissues (Zuo et al., 2019), enhancing resistance to inflammation, maintaining immune function and stabilizing the internal environment (Wande et al., 2020)

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Dissolve in sterile ultrapure water or PBS (pH 7.07.4). Due to its susceptibility to oxidation, prepare fresh working solutions under inert atmosphere where possible. Store reconstituted solution at 4C and use within 2448 hours; or aliquot and store at 80C for longer-term stability

Attenuation of glomerular hyperfiltration results in prevention of long-term glomerular damage, contributing to reduce the progression of diabetic kidney disease (DKD) ( Figure 1 The increased sodium delivery to the macula densa theoretically results in low renin levels per se