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J Neurosci 2012;32:322-330

In SUSTAIN 7, gastrointestinal side effects occurred at comparable rates across both medications

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Carnitine acetyltransferase (CrAT) can act as safety valve to catalyze the reversible transfer of acetyl groups between acetyl-CoA and acetylcarnitine, promoting the combination of excess acyl groups with carnitine, increasing the membrane permeability of these products and thus removing them from the mitochondria, allowing acylcarnitine to be formed in the mitochondrial matrix and exported to the plasma [7]

Potential Clinical and Economic Impact of Switching Branded Medications to Generics

A Final Note On Tradeoffs And Choice People choose microdosing for understandable reasons, including tolerability and perceived control, but the tradeoff is uncertainty