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This is important for the development of vascular lesion because it shows that G6PD deficiency, while reducing the reactive nitrogen species, actually increases the production of ROSs that exert much more deleterious effects than NO itself [46]

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However, during high-fat diet (HFD) feeding, obesity and insulin resistance, the accumulation of medium-chain and long-chain acylcarnitines due to incomplete -oxidation may negatively regulate the expression of nuclear-encoded mitochondrial genes, further reducing mitochondrial number and function and creating a vicious metabolic cycle [33]