Mass cytometry Heavy-metal conjugation of antibodies Antibodies were conjugated to heavy-metal ions with commercially available Maxpar (Fluidigm) or MIBItag (Ionpath) reagents according to manufacturers instructions, and as previously described 30 (see Supplementary Data 2)
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A persistent metallic taste may interfere with hydration
This method provides a systemic and immediate delivery of the peptide
This is the proportion observed in the SURMOUNT-1 tirzepatide trial across age, sex, and weight-loss subgroups, and was similar for placebo participants who lost weight without medication 2
Wegovy is for weight reduction in obese adults (18 years and older) with a body mass index (BMI) of 30 kg/m 2 or higher or overweight adults with a body mass index (BMI) of 27 kg/m 2 or higher and at least one weight-related condition such as high blood pressure, high blood sugar, or high cholesterol