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Both of these processes are mainly regulated by the signaling pathway: insulin-like growth factor-1 (IGF-1) phosphoinositide-3-kinase (PI3K) protein kinase B (Akt) mammalian target of rapamycin (mTOR)

These signs could indicate a separate musculoskeletal condition unrelated to the medication

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PLoS Med 3:e420 Singh RK, van Haandel L, Kiptoo P, Becker ML, Siahaan TJ, Funk RS (2019) Methotrexate disposition, anti-folate activity and efficacy in the collagen-induced arthritis mouse model