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Tirzepatide: The First GLP-1/GIP Dual Agonist Tirzepatide is a dual incretin agonist that activates both the glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) receptors and was developed to enhance metabolic and weight-loss outcomes beyond those achieved with GLP-1 receptor agonists alone

Dosing and Titration Dosing for GLP-1 receptor agonists typically starts low and gradually increases to minimize side effects

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Last reviewed: July 8, 2026 Last updated: July 8, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations

If youve been following the rise of GLP-1s as obesity drugs, this is a story worth watching

Others need the third or fourth tier