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However, prolonged exogenous IGF-1 suppressed the p53/progerin pathway to diminish hepatocyte premature senescence through activating the PI3K/AKT1 pathway (Supplementary Fig
In ISO-induced myocardial infarction, pretreatment with Gln maintained cardiac GSH kurtosis and antioxidant enzyme (GPX, SOD, CAT) activity at near-normal levels, thus preventing oxidative damage in the myocardium [111]
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- Support the skin barrier
The skin attributes improved at 12 weeks (as assessed by blind expert graders) for elasticity, wrinkles, and evenness in different body areas (face, hands, neck, etc.) compared with placebo measurements
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