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In support of this, we found that the effect of liraglutide to increase alpha-cell GLP-1 expression necessitates intact beta-cell GLP-1R signaling ( Figure 5 In comparison to GLP-1R agonists, DPP-IV inhibitors decrease the enzymatic degradation of endogenously produced GLP-1, thereby potentiating incretin signaling pathways, albeit with lower potency than GLP-1R agonists, yet fewer adverse effects (112)

115 In a word, disturbances in estrogen homeostasis in the breast tissue may promote breast cancer progression and metastasis

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10.1002/advs.201900962 166 SolM.Esteban-LopezM.TaltavullB.FbregasC.FadR.CasalsN.et al