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By synthesizing evidence across these domains, this review argues that the primary barriers to development have historically been technological and conceptual rather than biological

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In addition to the gut-brain and gut-kidney axes, the gut microbiota systemically communicates through other axes such as the gut-liver (Albillos et al., 2020), gut-heart (Zhao et al., 2023), gut-skin (Sinha et al., 2021), and gut-bone (Zhang et al., 2024) axes, among others

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This ones important because impurity profilesespecially potential genotoxic impuritiesare going to get close attention from FDA, EMA, whoever your regulatory path involves