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Der-Nigoghossian, C
Given that type 2 diabetes itself is a risk factor for nonarteritic anterior ischemic optic neuropathy [which constitutes approximately 75% of ischemic optic neuropathy cases] the potential for GLP-1 receptor agonists to further augment this risk has relevant implications for clinical decision making.
Molecular weight approximately 1,419 Da, small enough to cross most biological barriers including the blood-brain barrier in animal models
supervised settings only
Our work [45] and that of Jaiswal group [46] suggest that c-Jun is the predominant activating partner and that the small Mafs as well as c-Myc are inactivators of transcription when bound to Nrf2 [40, 47]
Furthermore, meta-analysis including 165 clinical trials reaffirmed these findings showing no evidence of elevated risk of pancreatitis or pancreatic cancer [69], assuring the safety of alogliptin
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