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Key takeaways Vitamin B12 deficiency can cause headaches and may be linked to chronic migraine

Avoid taking it late in the day: Some B vitamins, like B12, can boost energy levels, so taking them too late might interfere with sleep

Copper itself is an essential cofactor for numerous enzymes involved in collagen synthesis (lysyl oxidase), antioxidant defense (superoxide dismutase) and melanin production (tyrosinase)