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According to the practice guideline from Europe proposed in 2016, pharmacotherapies should be considered for NASH patients with fibrosis stage 2 or higher and with early stage fibrosis with high risk of fibrosis progression (older age, diabetes, metabolic syndrome, increased ALT, and high necroinflammatory activity) [5]

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Intentionally undereating is not necessary

When you activate GLP-1 receptors in the stomach lining and chemoreceptor trigger zone (a nausea-control region in the brain), your stomach empties more slowly, signaling fullness faster

The interaction isnt universal toxicity but pathway interference at concentrations that individual compound safety profiles dont predict