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For any compound to work transdermally, it must be small enough to penetrate through multiple skin layers and achieve therapeutic concentrations in the bloodstream

doi: 10.1111/apt.13227 80 SmithE

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However, the oral GLP-1 product, Rybelsus, has low bioavailability and requires cumbersome daily administration, which reduces its convenience

As demand increased, several challenges followed

The specific criteria for inclusion and exclusion of relevant studies in terms of PI(E)COS (Population, Intervention/Exposure, Comparison, Outcomes, and Study design) are provided in Table 1