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The consistent clinical failure of agents targeting a single mode of cell death provides compelling clinical validation for the mechanistic principle outlined in Section 2.4.2: MIRI triggers an interconnected web of cell death programs, suggesting future strategies may need to be multi-modal or target more upstream events

Treatment Discontinuation The rate of treatment discontinuation due to adverse events is a practical measure of a drug's overall tolerability in a clinical trial setting

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Understanding Contraceptive Failure Contraceptive failure means that the method of birth control did not prevent pregnancy