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N Engl J Med 2019;381:19952008.PubMed 49

Step 6. Protect

4.2 Targeting Gln metabolism to inhibit tumor proliferation 4.2.1 Inhibition of Gln uptake Tumor survival and proliferation are heavily dependent on Gln, a hydrophilic amino acid that must be transported into tumor cells by transmembrane proteins, such as SLC1A5, SLC6A14, and SLC38A1/2