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Front Endocrinol (2018) 9:706

Cancer drug resistance: an evolving paradigm

Zhong et al., 2013), and recent genetic investigations of breast cancers revealed the crucial role of Nrf2 in oncogenesis ( In breast cancer, Nrf2 activation enhances Rho expression and downstream proteins such as focal adhesion kinase 1 (FAK), modulator of volume-regulated anion channel current 1 (MLC), and Rho-associated coiled-coil-containing protein kinase 1 (ROCK), whereas it lowers estrogen-related receptor (ERR1) expression

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