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Moreover, whether the exosomes continuously secreted by the engineered cells, as a delivery vector themselves, will transfer the genetic modification effects laterally to distant tissue cells and thereby cause toxicity, is also an urgent issue that needs to be deeply clarified as a safety concern [168]

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HLA-DR values were diminished statistically in the MAHT at 8 mg, but with the other two kind of treatments they had a gentle no significant reduction

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Marra, F., Gastaldelli, A., Svegliati Baroni, G., Tell, G