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Drug metabolic pathways are divided into phase I and phase II reactions

Tumor Thickness at the Tumor-normal Interface: A Novel Pathologic Indicator of Chemotherapy Response in Hepatic Colorectal Metastases 34(9):1287-1294, 2010

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Image Credits : AI Generated DOI : 10.1038/s41537-026-00784-5

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At this point, it is important to note that although there seems to be a trend suggesting a correlation between the number of interactions in the GST-GSH complexes and their affinity (Fig 6B), this is still an approximation that requires further analysis with more accurate computational methods to determine binding free energies