The direct answer is no, current guidance recommends against using GLP-1 medications while breastfeeding, and the reasoning is worth understanding in detail
long-acting GLP 1RAs are administered once daily (liraglutide) or once weekly (slow-release exenatide, dulaglutide, albiglutide)
However, contact your healthcare provider if you notice: Persistent fatigue beyond typical medication adjustment Upper right abdominal discomfort Dark urine or pale stools Yellowing of skin or eyes (jaundice) Nausea that worsens rather than improves over time These symptoms are uncommon but warrant evaluation
GLP-1RA = Glucagon-like peptide-1 receptor agonist
Studies demonstrate that patients losing less than 5% body weight at early checkpoints rarely achieve clinically meaningful outcomes with continued treatment
Our review was based on a systematic PubMed search of randomized controlled trials (RCTs), observational studies, systematic reviews/meta-analyses, literature reviews, and case reports, published up to 2022, evaluating the combined treatment with a GLP-1RA and a SGLT2i in T2DM or prediabetes