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When applied to skin, it's converted through a two-step enzymatic process - first to retinaldehyde, then to retinoic acid - before it becomes biologically active

How Weight Loss Affects Hormone Levels When you lose weight, it changes your hormone levels

AJP Gastrointest Liver Physiol 295:G1202G1210

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Since the results we observed could be related to the inability of these tests to reproduce the same conditions as the ones observed in the gastrointestinal tract for the exposure experiments ( i.e