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Furthermore, systemic depletion of GSH may lower the bodys ability to address oxidative stress, especially in pancreatic -cells which lack both extensive antioxidant capacity and capabilities to repair damaged DNA [58]

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Cysteine Substrate Shortage: Oxidative stress prematurely converts cysteine, the rate-limiting GSH precursor, into inactive forms

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Reactive oxygen species (ROS) regulates different types of cell death by acting as a rheostat