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Key warning signs include the presence of SIRS, 175 evidence of hypovolemia (such as elevated BUN 176 and hematocrit 177 ), obesity, 178 pleural effusion and/or pulmonary infiltrates, 179 and altered mental status

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The most common side effects are gastrointestinal symptoms like nausea, vomiting, and diarrhea

These effects could be attributed to the ability of AST to mitigate oxidative damage, reduce lipid peroxidation and inflammation, and maintain the cells integrity 73

The Adrenal and Thyroid Connection Cortisol functions in a negative feedback loop with the hypothalamus and pituitary gland

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