When to seek medical advice : Patients should contact their GP, diabetes specialist nurse, or NHS 111 urgently if they experience: Severe, persistent abdominal pain, especially if radiating to the back (possible pancreatitis) Persistent vomiting (unable to keep down fluids for more than 24 hours) Signs of dehydration (extreme thirst, dry mouth, reduced urination, dizziness) Fever, jaundice, or right upper abdominal pain (possible gallbladder disease) If nausea significantly impacts their ability to maintain adequate nutrition These symptoms may warrant dose reduction, temporary treatment interruption, or switching to an alternative GLP-1 preparation with a potentially better tolerability profile
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Stimulant-based medications Stimulant-based medications may not be appropriate for patients with uncontrolled blood pressure, certain heart rhythm issues, significant anxiety, or significant insomnia
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Pay attention to how you feel, not just intoxication levels
Considerations for People Using Semaglutide for Weight Loss People who use Semaglutide for weight loss should be especially mindful of these potential interactions
