Astrocyte decrease in the subgenual cingulate and callosal genu in schizophrenia
The molecules are too large to pass through the skin barrier in significant amounts, making digestive side effects extremely unlikely from topical use
Potential side-effects, interactions (especially in vulnerable populations)
Antidepressant-like effect of genipin in mice
Notably, GLP-1 agonists exhibit direct effects on adipose tissue by promoting lipolysis and inhibiting lipogenesis, leading to reduced fat accumulation (298)

Cosmetic composition, comprising in a cosmetically acceptable medium at least one polymeric, ionic compound comprising imidazolium groups (imidazolium compound A), obtainable by reacting a) at least one a-dicarbonyl compound, b) at least one aldehyde, c) at least one amino compound having at least two primary amino groups, d) optionally an amino compound having only one primary amino group and e) at least one protic acid, and optionally subjecting the reaction product to an anion exchange, where the main chain of the at least one compound comprising imidazolium groups does not contain benzene rings, and where in the components a) and b) the aldehyde carbonyl groups may also be present as hemiacetal or acetal and the ketone carbonyl groups may also be present as hemiketal or ketal, and optionally at least one antidandruff agent different from the imidazolium compound