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When LPS penetrates, the endotoxemia stimulates innate immune response, triggering systemic inflammation and aggravating neuroinflammation [115]

The peptide demonstrates stability in gastric environments and resistance to enzymatic degradation

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Ethics declarations Competing interests J.A., M.C., A.E

For chronic GI conditions including irritable bowel syndrome, inflammatory bowel disease, gastritis, and peptic ulcers, the peptide may offer unique benefits

Its discovery originated from studies comparing human plasma from young and older adults, with the younger plasma being more effective in inducing macromolecular synthesis in rat hepatocytes and hepatoma cells [8, 9]