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Before the rats were dosed with testosterone, some of the animals were given injections of the carcinogenic chemical N-nitroso-N-methylurea (MNU)

Exposure to excessive heat or freezing temperatures can denature the protein-based medication, rendering it ineffective

It is believed to be due to autoimmune induced damage to the thyroid causing excess hormone release, and for this reason is not responsive to antithyroid drugs, KI or KCLO 4 , but does, if treatment is necessary, respond to prednisone(67)

In general, dose increases are typically spaced at least 4 weeks apart to help assess tolerability

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Any discrepancies between the reviewers were resolved through discussion to reach a consensus