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In our previous studies, we demonstrated that both GLP-1 receptor agonists (GLP-1RAs) liraglutide and exenatide, as well as an SGLT-2i, dapagliflozin, could activate various nuclei and pathways in the CNS of Sprague Dawley (SD) rats and C57BL/6 mice, respectively

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doi:10.1111/dom.12932

One journal

Samples were removed from the water bath, 250 NRS was added, and each was placed into a rotisserie hybridization oven at 37C with rotation at high speed for the appropriate incubation time (10, 20, 30 40 or 60 minutes)

With a dose three times the standard maximum, the core question for practitioners is safety