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First, a bacterial reverse mutation test (Ames test) assessed AOD9604s mutagenic potential using four histidine-dependent auxotrophic mutants of Salmonella typhimurium (TA1535, TA1537, TA98, TA100) and one tryptophan-dependent auxotrophic mutant of Escherichia coli (WP2 uvrA), using both plate incorporation and pre-incubation methods at doses of 0, 1.6, 8, 40, 200, 1,000, and 2,000 g AOD9604/plate

It used a ShapiroWilk test to assess normality and an F-test to assess homoscedasticity, and attempted log-transformation to resolve any lack thereof 40

There is no population for whom use of this compound is supported by evidence

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Bates CJ, Schneede J, Mishra G, et al

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