Across the SLD spectrum, GLP-1 RAs demonstrated modest but directionally consistent improvements in liver enzyme profiles (alanine aminotransferase [ALT] and aspartate aminotransferase [AST]), with 4 of the 7 ALT outcome estimates showing significant reductions, and 4 of the 9 AST outcome estimates showing significant reductions
GLP-1R is expressed in feeding-related nuclei in the hypothalamus and brainstem (47, 48), and knockout from glutamatergic but not GABAergic neurons almost entirely abrogates GLP-1R agonist-induced weight loss in obese mice (49)
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The global peptide therapeutics market was valued at over $39.5 billion in 2023
Based on this study, the D allele has a beneficial effect on the onset of therapy for depression and can be used as a predictor of faster onset of different antidepressant treatments, but the I-allele seemed to have a delayed effect on therapy (74)
