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In the case of the PPAR- agonist drugs, the most widely anticipated additional benefit was decreased vascular disease because of favorable effects of the drug class on risk factors for vascular disease supported by murine studies reporting protection against ischemic heart disease (3)

The neuroprotective effects appear partially mediated through IGF-1 elevation secondary to GH release, as IGF-1 is a well-established neuroprotective factor with effects on neuronal survival and synaptic plasticity

This can cause night sweats, palpitations, vivid dreams, and disrupted sleep, requiring dose adjustments of these medications under GP supervision

Pregnancy and lactation: Insufficient safety data exists for MOTS-c use during pregnancy or breastfeeding