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Chem Eng J, 2023, 452: 139108 Cheng L, Wang X, Gong F, et al

In additional validation experiments, we generated conditional knockout mice for Slc25a39

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All participants had a diagnosis of ASD established with DSM-IV-TR or DSM-5 and validated with ADOS-2 and/or ADI-R, while individuals with neurological or psychiatric comorbidities, recent probiotic or oxytocin use, or unstable medications were excluded

In conclusion, in this post hoc analysis of the SURMOUNT-5 trial, a significantly greater proportion of participants with obesity and prediabetes at baseline reverted to normoglycemia following 72 weeks of treatment with tirzepatide as compared with semaglutide, with clinically significant reductions in body weight and waist circumference