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Amino acids metabolic substrates enhance insulin sensitivity and responsiveness of the protein synthesis system by increasing mTOR activity and inhibiting protein degradation in liver, muscle, and heart tissues

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These include the Mas-related G protein-coupled receptors (Mrgpr) family as well as transient receptor potential ankyrin 1 (TRPA1) and protease activated receptor 2 (Par2) [78]

The agency also notes possible risks related to immune reactions, peptide-related impurities, and difficulties in fully characterizing the active pharmaceutical ingredient