The copper component of GHK-Cu is integral to its biological activity
251,273,274 Hypertensive animal models, such as Ang II-induced hypertensive rats, 275 SHR, 276 DOCA-salt hypertensive rats, and two-kidney two-clip renovascular hypertensive rats, have been shown to exhibit increased expression and activity of NADPH oxidase or its cytosolic subunits
The key lies in the growth hormone component
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