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Given that AgRP and NPY, which are activated under similar conditions and have comparable effects, it is indicative that they very likely evolved to ensure the signaling of hunger during food scarcity and to enable the body to endure long periods of negative energy balance

A new generation of appetite-suppressing, injectable drugs called GLP-1 agonists has become immensely popular in the last few years, transforming the treatment for obesity and diabetes in many countries

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Its also often prescribed off-label to support weight loss in people living with obesity

A review by Alorfi et al

doi: 10.1128/MCB.00256-14 66 AkbariPGilaniASosinaOKosmickiJAKhrimianLFangYYet al