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GLP-1 receptors are expressed in the heart muscle cells, immune system cells in the heart, and in the lining of blood vessels.[ref] GLP-1 RAs have been shown to help in heart failure and also to have beneficial effects on heart rhythm.[ref] Related article : Cardiovascular disease genetic risk factors Cancer Research: Retatrutide, a GLP-1/GIP/GCG triple agonist, has recently been shown to reduce pancreatic tumor mass in animals

Dans les tudes de phase 3, une raction au point dinjection a t observe chez 0,6 % des patients sous 0,5 mg, 0,3 % sous 1 mg, et 0,8 % dans les groupes comparateurs

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Its activity increases with hepatocellular damage [85]