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Studies have shown that SC MTX has a better bioavailability than oral MTX (Hoekstra et al

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Pendula radix] bark methanolic extract enhanced an oxidative cellular microenvironment, leading to ferroptosis-mediated CaCo2 cell death by HO-1 hyper-expression (Malfa et al., 2019)

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Quality control Country of origin : Asia, Europe and North America How sourced : Cultivated and wild-harvested Risks : Adulteration with other species of Silybum and the use of synthetic colorants and depleted extracts Key marker compounds : Silymarin and flavonoids Milk thistle ( Silybum marianum ) contains flavanolignans, flavonoids, and fixed oils based principally on linoleic and oleic acid (19)