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Recently, Mazza and colleagues demonstrated bilirubins antioxidant and cytoprotective effects in relation to damage to endothelial cells mediated by angiotensin II (38)

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These dynamic and heterogeneous shifts in cell death modalities across disease stages and brain regions significantly complicate PD treatment, necessitating in-depth research to develop targeted therapeutic strategies

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[PubMed: 31343010] (Among 50 Iranian patients with nonalcoholic fatty liver disease treated with ALA [600 mg] or placebo twice daily for 12 weeks, changes in serum ALT and AST, body weight and the intensity of hepatic steatosis did not differ in the two treatment arms, although measures of insulin sensitivity and adiponectin levels improved more with ALA treatment)

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