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In VENTURE, overall TEAEs were common (as with the class), with gastrointestinal events predominating and generally front-loaded early in titration before settling over time

Evidence for a general amino acid permease

High-altitude hypoxia exposure induces iron overload and ferroptosis in adipose tissue

The Mouse Metabolic Phenotyping Center allowed us to make measurements with a level of precision thats difficult to achieve elsewhere. The extended timeline revealed a striking parallel between mice and humans treated with GLP-1R agonists: weight loss that unfolds in three distinct stages

a , e , i , Venn-diagram with number of differentially expressed genes (DEGs

Methods Detailed methods are reported in supplemental materials