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"I highly recommend implementing diet, exercise and lifestyle changes with or without the medications," Carpenter comments

The accumulation of melanin in basal layer cells is confined to the tips of epithelial rete ridges, which has been reported and observed through a review of the histopathologic findings in some reported cases[5,6,11,15,19,40,62,67,85]

Interpretation and validity of changes in scores on the Graves ophthalmopathy quality of life questionnaire (GO-QOL) after different treatments