semaglutide resting heart rate Tirzepatide & Rate: Cardiovascular Safety Guide – PlexusDx Does Semaglutide Cause Heart Palpitations?

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PloS One 13, e0193473

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Patients who experience palpitations beyond 8 weeks at a stable dose should undergo formal cardiac evaluation including ECG and Holter monitoring to rule out arrhythmia unrelated to normal GLP-1 adaptation

Patients who are also optimizing hormonal status should be aware that sex hormones interact with MOTS-c signaling

Semaglutide and HRT operate through different biological pathways and do not interact directly