Peer Review under the responsibility of Associao Brasileira de Otorrinolaringologia e Cirurgia Crvico-Facial.
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Quercetin and tangeretin primarily enhance mitochondrial biogenesis by activating the AMPK/PGC1-/NRF1/transcription factor A, mitochondrial (TFAM) signaling pathway, which increases mitochondrial DNA replication and gene transcription
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