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Retatrutide and tirzepatide both target hormones involved in appetite and blood sugar control, but there are key differences

Hormonal imbalances can influence lipid metabolism, exacerbating dyslipidemia and increasing the risk of cardiovascular disease

Data sharing The data that support the findings of this study were licensed from Truveta

Notably, weight loss continued throughout the trial period, with no plateau observed

Crash diets can lower leptin levels, increasing appetite and slowing metabolism, which often leads to regaining lost weight

Concerns about pancreatitis or certain cancers have lingered (though data so far supports safety), and a black swan event could crater demand