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mHealth applications purpose-built for ePRO collection have demonstrated non-inferiority to paper-based instruments in multiple psychometric validation studies, supporting regulatory submissions across FDA, EMA, and PMDA jurisdictions

Most patients notice results within a few days

Assessment of treatment efficacy in the setting of CRPC remains a challenge

FEBS Lett 480: 193196

Because these findings are largely based on laboratory and animal studies, expected outcomes in humans are uncertain and may vary by individual, dose, and the underlying condition

The GRAS designation has created regulatory ambiguity: while AOD-9604 supplements are legally available, their marketing often implies therapeutic benefits that remain unproven