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RCTs with rigorous lifestyle control [e.g., standardized physical activity protocols] are needed to confirm causal relationships

Chronic fatigue syndrome (CFS) is characterized by extreme, long-lasting fatigue not improved by rest

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doi: 10.1210/endo.137.12.8940406 96 SymondsMEPhillipsIDAnthonyRVOwensJAMcMillenIC

Some people experience mild digestive upset when first starting, especially on an empty stomach

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