The evidence is beginning to catch up
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Western blot analysis revealed that protocatechuic acid downregulated Keap1 expression and activated the Nrf2/HO-1 signalling pathway, and activation of the Nrf2/HO-1 pathway resulted in an antioxidant effect that reduced ROS and MDA levels, increased SOD expression and subsequently inhibited RA-FLS migration, and invasion, and increased apoptosis
The cells were first collected by centrifugation at 12,000 g for 5 min, resuspended in RNA later Solution (Ambion), and harvested from the RNA later suspension by centrifugation after overnight storage at 4C
Although GLP1RA often cause super-physiological levels of GLP1R activation, this study provides evidence that GLP1R signaling may decrease cancer risk
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