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The Root Cause Triad: Immune Dysregulation, Gut Dysfunction, and Inflammation Foundational therapies can struggle to break this self-perpetuating cycle, where gut health, inflammation, and immune response are all linked

31 Medina-CalizI.Robles-DiazM.Garcia-MuozB.StephensC.Ortega-AlonsoA.Garcia-CortesM.et al (2016)

Moderated dosing and timing are everything

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Phase 2 trial data (Jastreboff et al., NEJM 2023) identified nausea, vomiting, diarrhoea, and constipation as the most common GI side effects