5).17 The main described causes are physiological aspects (racial melanonychia and pregnancy), mechanical trauma, post-inflammatory melanonychia (post-inflammatory hyperpigmentation), local infections (fungal or bacterial), drug-induced melanonychia (hydroxyurea, tetracyclines, amlodipine, psoralens, zidovudine or some chemotherapeutic agents, mainly cyclophosphamide, doxorubicin, and capecitabine), systemic diseases (hemosiderosis, HIV, porphyria, alkaptonuria, Addison disease, and Cushing syndrome), specific syndromes (Laugier-Hunziker-Baran, and Peutz-Jeghers syndromes), iatrogenic (phototherapy), and associated with keratinocyte nail tumors (onychomatricoma, onychocytic matricoma, onychopapilloma, and Bowen disease).17,21,2426 Melanocytic activation is usually asymptomatic, and dermoscopy of the nail plate surface reveals, in the majority of cases, a gray background color associated with parallel, thin, and regular lines.17,27,28 However, in individuals with phototypes IV, V, and VI, it may manifest as a brown or black discoloration (Fig

PlexusDx helps patients understand how fasting and injectable or oral medications work togetherand whether this combination aligns with your personalized health goals
The figures were created with Biorender.com
Ask the prescriber about your medication, health history, and alcohol use rather than relying on a universal limit
Vitamin C & E Fades pigmentation and boosts skin glow
For patients focused on stronger weight loss, standard-dose semaglutide or tirzepatide may be the better starting point