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Astrocytic gamma-aminobutyric acid dysregulation as a therapeutic target for posttraumatic stress disorder

doi: 10.1590/S1676-24442004000300006 176 Chvarri-GuerraYBourlonMTRodrguez-OlivaresJLOrozcoLBazuaDRodrguez-FaureAet al

However, when external triggers like UV rays or pollution enter the picture, the production of free radicals can skyrocket

The risk variant PTPN22 (R620W) encodes a hyperactive phosphatase that paradoxically attenuates T-cell receptor signaling, leading to aberrant thymic selection and escape of autoreactive lymphocytes

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There is no need to pinch the skin excessively in most patients, though individuals with minimal subcutaneous fat may benefit from a gentle skin fold to ensure subcutaneous rather than intramuscular injection